Working in cartoony characters I use an animation program now called Moho Pro. I'ts got a line width tool where you can select between one and all the nodes in a line and make it thicker or thinner. Adds alot of freedom to your design element. I use a wacom tablet but sometimes I want to adjust it just alittle more. I'm using 2019 don't know of away to do this so I put it under new feature.